Nudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling

Cell fate transitions involve rapid gene expression changes and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we identified the RNA-processing factor Nudt21 as a novel regulator of cell fate change using transcription factor induced reprogr...

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Pubblicato in:Cell
Autori principali: Brumbaugh, Justin, Di Stefano, Bruno, Wang, Xiuye, Borkent, Marti, Forouzmand, Elmira, Clowers, Katie J., Ji, Fei, Schwarz, Benjamin A., Kalocsay, Marian, Elledge, Stephen J., Chen, Yue, Sadreyev, Ruslan I., Gygi, Steven P., Hu, Guang, Shi, Yongsheng, Hochedlinger, Konrad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766360/
https://ncbi.nlm.nih.gov/pubmed/29249356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.023
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