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A reprogrammable mouse strain from gene targeted embryonic stem cells

The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here, we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction o...

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Hlavní autoři: Stadtfeld, Matthias, Maherali, Nimet, Borkent, Marti, Hochedlinger, Konrad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987893/
https://ncbi.nlm.nih.gov/pubmed/20010832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1409
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