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Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients
Human primary glioblastomas (GBM) often harbor mutations within the epidermal growth factor receptor (EGFR). Treatment of EGFR-mutant GBM cell lines with the EGFR/HER2 tyrosine kinase inhibitor lapatinib can effectively induce cell death in these models. However, EGFR inhibitors have shown little ef...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766249/ https://ncbi.nlm.nih.gov/pubmed/29293494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005924 |
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