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XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys(63)-linked polyubiquitination

The cellular response to hypoxia is characterised by a switch in the transcriptional program, mediated predominantly by the hypoxia inducible factor family of transcription factors (HIF). Regulation of HIF1 is primarily controlled by post-translational modification of the HIF1α subunit, which can al...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Park, Catherine V., Ivanova, Iglika G., Kenneth, Niall S.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766203/
https://ncbi.nlm.nih.gov/pubmed/28666324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx549
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