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Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study

Human matrix metalloproteinase proMMP-9 is secreted as latent zymogen, which requires two-steps proteolytic activation. The secreted proMMP-9 is glycosylated at two positions: Asn38 and Asn120 located in the prodomain and catalytic domain, respectively. It has been demonstrated that glycosylation at...

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Foilsithe in:PLoS One
Main Authors: Kumar, Sonu, Cieplak, Piotr
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766141/
https://ncbi.nlm.nih.gov/pubmed/29329315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191157
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