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TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo
Matrix metalloproteinases (MMPs) are synthesized as latent proenzymes. A proteolytic cleavage event involving processing of the cysteine-rich N-terminal propeptide is required for their full activation. Previous in vitro studies indicated that activation of proMMP-2 can occur through formation of a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683068/ https://ncbi.nlm.nih.gov/pubmed/10827175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M001270200 |
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