Protein kinase- and lipase inhibitors of inositide metabolism deplete IP(7) indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP(7), is at a high level...

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Publicado no:Cell Signal
Main Authors: Rajasekaran, Subu Surendran, Illies, Christopher, Shears, Stephen B., Wang, Huanchen, Ayala, Thais S., Martins, Joilson O., Daré, Elisabetta, Berggren, Per-Olof, Barker, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765549/
https://ncbi.nlm.nih.gov/pubmed/29042286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.10.008
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