Protein kinase- and lipase inhibitors of inositide metabolism deplete IP(7) indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Inositol pyrophosphates have emerged as important regulators of many critical cellular processes from vesicle trafficking and cytoskeletal rearrangement to telomere length regulation and apoptosis. We have previously demonstrated that 5-di-phosphoinositol pentakisphosphate, IP(7), is at a high level...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Signal
Prif Awduron: Rajasekaran, Subu Surendran, Illies, Christopher, Shears, Stephen B., Wang, Huanchen, Ayala, Thais S., Martins, Joilson O., Daré, Elisabetta, Berggren, Per-Olof, Barker, Christopher J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science Ltd 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765549/
https://ncbi.nlm.nih.gov/pubmed/29042286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.10.008
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