Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells

Diphosphoinositol pentakisphosphate (IP(7)) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high K(m) for ATP of the IP(7)-generating enzymes, the inositol hexakisphosphate kinases (IP6K1 an...

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Publicado no:Cell Signal
Main Authors: Rajasekaran, Subu Surendran, Kim, Jaeyoon, Gaboardi, Gian-Carlo, Gromada, Jesper, Shears, Stephen B., dos Santos, Karen Tiago, Nolasco, Eduardo Lima, Ferreira, Sabrina de Souza, Illies, Christopher, Köhler, Martin, Gu, Chunfang, Ryu, Sung Ho, Martins, Joilson O., Darè, Elisabetta, Barker, Christopher J., Berggren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899964/
https://ncbi.nlm.nih.gov/pubmed/29522819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2018.03.001
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