Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Pulmonary hypertension is characterized by pulmonary endothelial dysfunction. Previous work showed that systemic artery endothelial cells (ECs) express hemoglobin (Hb) α to control nitric oxide (NO) diffusion, but the role of this system in pulmonary circulation has not been evaluated. We hypothesiz...

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Detaylı Bibliyografya
Yayımlandı:Am J Respir Cell Mol Biol
Asıl Yazarlar: Alvarez, Roger A., Miller, Megan P., Hahn, Scott A., Galley, Joseph C., Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L., Rojas, Mauricio, Goncharova, Elena, Straub, Adam C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Thoracic Society 2017
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765416/
https://ncbi.nlm.nih.gov/pubmed/28800253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0418OC
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