Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Pulmonary hypertension is characterized by pulmonary endothelial dysfunction. Previous work showed that systemic artery endothelial cells (ECs) express hemoglobin (Hb) α to control nitric oxide (NO) diffusion, but the role of this system in pulmonary circulation has not been evaluated. We hypothesiz...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Alvarez, Roger A., Miller, Megan P., Hahn, Scott A., Galley, Joseph C., Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L., Rojas, Mauricio, Goncharova, Elena, Straub, Adam C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2017
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765416/
https://ncbi.nlm.nih.gov/pubmed/28800253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0418OC
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