Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Pulmonary hypertension is characterized by pulmonary endothelial dysfunction. Previous work showed that systemic artery endothelial cells (ECs) express hemoglobin (Hb) α to control nitric oxide (NO) diffusion, but the role of this system in pulmonary circulation has not been evaluated. We hypothesiz...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Alvarez, Roger A., Miller, Megan P., Hahn, Scott A., Galley, Joseph C., Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L., Rojas, Mauricio, Goncharova, Elena, Straub, Adam C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765416/
https://ncbi.nlm.nih.gov/pubmed/28800253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0418OC
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