Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Pulmonary hypertension is characterized by pulmonary endothelial dysfunction. Previous work showed that systemic artery endothelial cells (ECs) express hemoglobin (Hb) α to control nitric oxide (NO) diffusion, but the role of this system in pulmonary circulation has not been evaluated. We hypothesiz...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Alvarez, Roger A., Miller, Megan P., Hahn, Scott A., Galley, Joseph C., Bauer, Eileen, Bachman, Timothy, Hu, Jian, Sembrat, John, Goncharov, Dmitry, Mora, Ana L., Rojas, Mauricio, Goncharova, Elena, Straub, Adam C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765416/
https://ncbi.nlm.nih.gov/pubmed/28800253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0418OC
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