Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia

Adult T‐cell leukemia (ATL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Recent integrated‐genome analysis has revealed mutations in many genes involved in the T‐cell signaling pathway, suggesting that the aber...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Kawata, Takahito, Tada, Kohei, Kobayashi, Masayuki, Sakamoto, Takashi, Takiuchi, Yoko, Iwai, Fumie, Sakurada, Maki, Hishizawa, Masakatsu, Shirakawa, Kotaro, Shindo, Keisuke, Sato, Hironori, Takaori‐Kondo, Akifumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765289/
https://ncbi.nlm.nih.gov/pubmed/29077243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13431
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