Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia

Adult T‐cell leukemia (ATL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Recent integrated‐genome analysis has revealed mutations in many genes involved in the T‐cell signaling pathway, suggesting that the aber...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Kawata, Takahito, Tada, Kohei, Kobayashi, Masayuki, Sakamoto, Takashi, Takiuchi, Yoko, Iwai, Fumie, Sakurada, Maki, Hishizawa, Masakatsu, Shirakawa, Kotaro, Shindo, Keisuke, Sato, Hironori, Takaori‐Kondo, Akifumi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765289/
https://ncbi.nlm.nih.gov/pubmed/29077243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13431
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