HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). We recently reported that abacavir, an anti-HIV-1 drug, potently and selectively kills ATL cells. This effect was attributed to the reduced expression of tyrosyl-DNA-phosphodiesteras...

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Publicado no:Sci Rep
Main Authors: Takiuchi, Yoko, Kobayashi, Masayuki, Tada, Kohei, Iwai, Fumie, Sakurada, Maki, Hirabayashi, Shigeki, Nagata, Kayoko, Shirakawa, Kotaro, Shindo, Keisuke, Yasunaga, Jun-ichirou, Murakawa, Yasuhiro, Rajapakse, Vinodh, Pommier, Yves, Matsuoka, Masao, Takaori-Kondo, Akifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634466/
https://ncbi.nlm.nih.gov/pubmed/28993637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12924-0
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