Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury

Excessive fatty acid release from the white adipose tissue (WAT) contributes to the development of alcoholic liver disease (ALD). Lipin1 (LPIN1), as a co-regulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that dephosphorylates PA to form diacylglycerol...

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Udgivet i:Sci Rep
Main Authors: Zhang, Wenliang, Zhong, Wei, Sun, Qian, Sun, Xinguo, Zhou, Zhanxiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765113/
https://ncbi.nlm.nih.gov/pubmed/29323242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18837-2
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