Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease

Alcohol metabolism in the liver generates highly toxic acetaldehyde. Breakdown of acetaldehyde by aldehyde dehydrogenase 2 (ALDH2) in the mitochondria consumes NAD(+) and generates reactive oxygen/nitrogen species, which represents a fundamental mechanism in the pathogenesis of alcoholic liver disea...

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Publicat a:Redox Biol
Autors principals: Hao, Liuyi, Sun, Qian, Zhong, Wei, Zhang, Wenliang, Sun, Xinguo, Zhou, Zhanxiang
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700831/
https://ncbi.nlm.nih.gov/pubmed/29156373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.11.005
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