Pharmacological activation of aldehyde dehydrogenase 2 reverses alcohol-induced hepatic steatosis and cell death in mice

BACKGROUND AND AIMS: Alcoholic liver disease is a major health issue worldwide, but effective therapies are currently unavailable. The present study tested the efficacy of Alda-1, an activator of aldehyde dehydrogenase 2, in treating alcoholic liver disease. METHODS: Male C57BL/6J mice were exposed...

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Publicado en:J Hepatol
Autores principales: Zhong, Wei, Zhang, Wenliang, Li, Qiong, Xie, Guoxiang, Sun, Qian, Sun, Xiuhua, Tan, Xiaobing, Sun, Xinguo, Jia, Wei, Zhou, Zhanxiang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949737/
https://ncbi.nlm.nih.gov/pubmed/25543082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.12.022
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