Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats

Objectives: The recommended zolpidem starting dose was lowered in females (5 mg vs. 10 mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown. We hypothesized that such differences were caused by known se...

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Udgivet i:Front Pharmacol
Main Authors: Peer, Cody J., Strope, Jonathan D., Beedie, Shaunna, Ley, Ariel M., Holly, Alesia, Calis, Karim, Farkas, Ronald, Parepally, Jagan, Men, Angela, Fadiran, Emmanuel O., Scott, Pamela, Jenkins, Marjorie, Theodore, William H., Sissung, Tristan M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983555/
https://ncbi.nlm.nih.gov/pubmed/27574509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00260
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