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Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function

BACKGROUND: Oxidative stress plays a crucial role in the development of alcoholic liver disease (ALD), however effective pharmacological treatments for oxidative injury is still lacking. The objective of this study was to determine whether inhibition of NADPH oxidase activity could reverse alcohol-i...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Sun, Qian, Zhang, Wenliang, Zhong, Wei, Sun, Xinguo, Zhou, Zhanxiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742866/
https://ncbi.nlm.nih.gov/pubmed/27634671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.09.009
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