Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters

FGF receptor 2 is involved in the formation of the neuromuscular junction (NMJ), but its in vivo ligand remains to be determined. Laser capture microdissection of the mouse spinal motor neurons (SMNs) revealed that Fgf18 mRNA is highly expressed in SMNs in adults. Expression of Fgf18 mRNA was the hi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ito, Kenyu, Ohkawara, Bisei, Yagi, Hideki, Nakashima, Hiroaki, Tsushima, Mikito, Ota, Kyotaro, Konishi, Hiroyuki, Masuda, Akio, Imagama, Shiro, Kiyama, Hiroshi, Ishiguro, Naoki, Ohno, Kinji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765005/
https://ncbi.nlm.nih.gov/pubmed/29323161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18753-5
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