R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5

At the neuromuscular junction (NMJ), acetylcholine receptor (AChR) clustering is mediated by spinal motor neuron (SMN)-derived agrin and its receptors on the muscle, the low-density lipoprotein receptor-related protein 4 (LRP4) and muscle-specific receptor tyrosine kinase (MuSK). Additionally, AChR...

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Published in:Sci Rep
Main Authors: Nakashima, Hiroaki, Ohkawara, Bisei, Ishigaki, Shinsuke, Fukudome, Takayasu, Ito, Kenyu, Tsushima, Mikito, Konishi, Hiroyuki, Okuno, Tatsuya, Yoshimura, Toshiro, Ito, Mikako, Masuda, Akio, Sobue, Gen, Kiyama, Hiroshi, Ishiguro, Naoki, Ohno, Kinji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916433/
https://ncbi.nlm.nih.gov/pubmed/27328992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28512
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