Position-specific binding of FUS to nascent RNA regulates mRNA length

More than half of all human genes produce prematurely terminated polyadenylated short mRNAs. However, the underlying mechanisms remain largely elusive. CLIP-seq (cross-linking immunoprecipitation [CLIP] combined with deep sequencing) of FUS (fused in sarcoma) in neuronal cells showed that FUS is fre...

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Detalhes bibliográficos
Publicado no:Genes Dev
Principais autores: Masuda, Akio, Takeda, Jun-ichi, Okuno, Tatsuya, Okamoto, Takaaki, Ohkawara, Bisei, Ito, Mikako, Ishigaki, Shinsuke, Sobue, Gen, Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441052/
https://ncbi.nlm.nih.gov/pubmed/25995189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.255737.114
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