High-speed atomic force microscopy reveals structural dynamics of [Formula: see text]-synuclein monomers and dimers

α-Synuclein (α-syn) is the major component of the intraneuronal inclusions called Lewy bodies, which are the pathological hallmark of Parkinson’s disease. α-Syn is capable of self-assembly into many different species, such as soluble oligomers and fibrils. Even though attempts to resolve the structu...

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Bibliografske podrobnosti
izdano v:J Chem Phys
Main Authors: Zhang, Yuliang, Hashemi, Mohtadin, Lv, Zhengjian, Williams, Benfeard, Popov, Konstantin I., Dokholyan, Nikolay V., Lyubchenko, Yuri L.
Format: Artigo
Jezik:Inglês
Izdano: AIP Publishing LLC 2018
Teme:
Special Topic: Single Molecule Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764752/
https://ncbi.nlm.nih.gov/pubmed/29604892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5008874
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