Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

BACKGROUND: Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an...

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Veröffentlicht in:BMC Syst Biol
Hauptverfasser: Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan Chakrapani, White, Jacob K., Yu, Hanry, Tucker-Kellogg, Lisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763301/
https://ncbi.nlm.nih.gov/pubmed/29322934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0508-z
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