Steady States and Dynamics of Urokinase-Mediated Plasmin Activation In Silico and In Vitro

Plasmin (PLS) and urokinase-type plasminogen activator (UPA) are ubiquitous proteases that regulate the extracellular environment. Although they are secreted in inactive forms, they can activate each other through proteolytic cleavage. This mutual interplay creates the potential for complex dynamics...

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Bibliografiske detaljer
Main Authors: Venkatraman, Lakshmi, Li, Huipeng, Dewey, C. Forbes, White, Jacob K., Bhowmick, Sourav S., Yu, Hanry, Tucker-Kellogg, Lisa
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2011
Fag:
Biological Systems and Multicellular Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192967/
https://ncbi.nlm.nih.gov/pubmed/22004735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.08.054
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