IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

CSF-1 and IL-34 share the CSF-1 receptor and no differences have been reported in the signaling pathways triggered by both ligands in human monocytes. IL-34 promotes the differentiation and survival of monocytes, macrophages and osteoclasts, as CSF-1 does. However, IL-34 binds other receptors, sugge...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Boulakirba, Sonia, Pfeifer, Anja, Mhaidly, Rana, Obba, Sandrine, Goulard, Michael, Schmitt, Thomas, Chaintreuil, Paul, Calleja, Anne, Furstoss, Nathan, Orange, François, Lacas-Gervais, Sandra, Boyer, Laurent, Marchetti, Sandrine, Verhoeyen, Els, Luciano, Frederic, Robert, Guillaume, Auberger, Patrick, Jacquel, Arnaud
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762882/
https://ncbi.nlm.nih.gov/pubmed/29321503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18433-4
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