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Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity
Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. We provide biochemical and developmental evidence identifying acetaldehyde as responsible for this inhibition. In the...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5762763/ https://ncbi.nlm.nih.gov/pubmed/29321611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18719-7 |
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