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A paradoxical teratogenic mechanism for retinoic acid

Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Nevertheless, it has long been recognized that overexposure to vitamin A or retinoic acid causes widespread teratogenesis in rodents as well as humans. Although it has a short half-life, exp...

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Detalhes bibliográficos
Main Authors: Lee, Leo M. Y., Leung, Chun-Yin, Tang, Walfred W. C., Choi, Heung-Ling, Leung, Yun-Chung, McCaffery, Peter J., Wang, Chi-Chiu, Woolf, Adrian S., Shum, Alisa S. W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427051/
https://ncbi.nlm.nih.gov/pubmed/22869719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200872109
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