Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes

Pregestational diabetes is highly associated with an increased risk of birth defects. However, factors that can increase or reduce the expressivity and penetrance of malformations in pregnancies in women with diabetes remain poorly identified. All-trans retinoic acid (RA) plays crucial roles in embr...

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Pubblicato in:Diabetes
Autori principali: Lee, Leo M.Y., Leung, Maran B.W., Kwok, Rachel C.Y., Leung, Yun Chung, Wang, Chi Chiu, McCaffery, Peter J., Copp, Andrew J., Shum, Alisa S.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365142/
https://ncbi.nlm.nih.gov/pubmed/28087565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1570
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