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Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity
Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. We provide biochemical and developmental evidence identifying acetaldehyde as responsible for this inhibition. In the...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5762763/ https://ncbi.nlm.nih.gov/pubmed/29321611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18719-7 |
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