Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression

Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we isolated FL/Doxo cells which are multi-drug resistant. Increased levels of drug eff...

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Publicat a:Oncotarget
Autors principals: Steelman, Linda S., Abrams, Steve L., Ruvolo, Peter, Ruvolo, Vivian, Cocco, Lucio, Ratti, Stefano, Martelli, Alberto M., Neri, Luca M., Candido, Saverio, Libra, Massimo, McCubrey, James A.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762570/
https://ncbi.nlm.nih.gov/pubmed/29348885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22956
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