Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer

BACKGROUND AND AIMS: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-mediated nuclear export may play a crucial ro...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gravina, Giovanni Luca, Mancini, Andrea, Colapietro, Alessandro, Marampon, Francesco, Sferra, Roberta, Pompili, Simona, Biordi, Leda Assunta, Iorio, Roberto, Flati, Vincenzo, Argueta, Christian, Landesman, Yosef, Kauffman, Michael, Shacham, Sharon, Festuccia, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762317/
https://ncbi.nlm.nih.gov/pubmed/29340049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22760
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