The Brain Penetrating and Dual TORC1/TORC2 Inhibitor, RES529, Elicits Anti-Glioma Activity and Enhances the Therapeutic Effects of Anti-Angiogenetic Compounds in Preclinical Murine Models

Background. Glioblastoma multiforme (GBM) is a devastating disease showing a very poor prognosis. New therapeutic approaches are needed to improve survival and quality of life. GBM is a highly vascularized tumor and as such, chemotherapy and anti-angiogenic drugs have been combined for treatment. Ho...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Gravina, Giovanni Luca, Mancini, Andrea, Colapietro, Alessandro, Delle Monache, Simona, Sferra, Roberta, Pompili, Simona, Vitale, Flora, Martellucci, Stefano, Marampon, Francesco, Mattei, Vincenzo, Biordi, Leda, Sherris, David, Festuccia, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826425/
https://ncbi.nlm.nih.gov/pubmed/31640252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101604
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