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Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase
KRAS is a regulator of the nutrient stress response in non-small cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of this pathway during nutrient stress...
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| 出版年: | Cancer Cell |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5761662/ https://ncbi.nlm.nih.gov/pubmed/29316436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.003 |
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