Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase

KRAS is a regulator of the nutrient stress response in non-small cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of this pathway during nutrient stress...

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Publicado no:Cancer Cell
Main Authors: Gwinn, Dana M., Lee, Alex G., Briones-Martin-del-Campo, Marcela, Conn, Crystal S., Simpson, David R., Scott, Anna I., Le, Anthony, Cowan, Tina M., Ruggero, Davide, Sweet-Cordero, E. Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761662/
https://ncbi.nlm.nih.gov/pubmed/29316436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.003
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