An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identificatio...

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Publicado no:Nat Commun
Main Authors: Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elisabet, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Valencia, Karmele, Arricibita, Andrea, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Guembe, Laura, Bailey, Peter, Chang, David K., Biankin, Andrew, Ponz-Sarvise, Mariano, Andersen, Jesper B., Khatri, Purvesh, Bozec, Aline, Sweet-Cordero, E. Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silve
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321758/
https://ncbi.nlm.nih.gov/pubmed/28220783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14294
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