Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Tumor cells adapt to nutrient-limited environments by inducing gene expression that ensures adequate nutrients to sustain metabolic demands. For example, during amino acid limitations, ATF4 in the amino acid response induces expression of asparagine synthetase (ASNS), which provides for asparagine b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jiang, Jie, Srivastava, Sankalp, Seim, Gretchen, Pavlova, Natalya N., King, Bryan, Zou, Lihua, Zhang, Chi, Zhong, Minghua, Feng, Hui, Kapur, Reuben, Wek, Ronald C., Fan, Jing, Zhang, Ji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901317/
https://ncbi.nlm.nih.gov/pubmed/31659118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010447
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