Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Tumor cells adapt to nutrient-limited environments by inducing gene expression that ensures adequate nutrients to sustain metabolic demands. For example, during amino acid limitations, ATF4 in the amino acid response induces expression of asparagine synthetase (ASNS), which provides for asparagine b...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Jiang, Jie, Srivastava, Sankalp, Seim, Gretchen, Pavlova, Natalya N., King, Bryan, Zou, Lihua, Zhang, Chi, Zhong, Minghua, Feng, Hui, Kapur, Reuben, Wek, Ronald C., Fan, Jing, Zhang, Ji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901317/
https://ncbi.nlm.nih.gov/pubmed/31659118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010447
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki