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A complex genomic locus drives mtDNA replicase POLG expression to its disease‐related nervous system regions
DNA polymerase gamma (POLG), the mtDNA replicase, is a common cause of mitochondrial neurodegeneration. Why POLG defects especially cause central nervous system (CNS) diseases is unknown. We discovered a complex genomic regulatory locus for POLG, containing three functional CNS‐specific enhancers th...
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| Udgivet i: | EMBO Mol Med |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760859/ https://ncbi.nlm.nih.gov/pubmed/29109127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707993 |
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