Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Mitochondrial dysfunction manifests as different neurological diseases, but the mechanisms underlying the clinical variability remain poorly understood. To clarify whether different brain cells have differential sensitivity to mitochondrial dysfunction, we induced mitochondrial DNA (mtDNA) depletion...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ignatenko, Olesia, Chilov, Dmitri, Paetau, Ilse, de Miguel, Elena, Jackson, Christopher B., Capin, Gabrielle, Paetau, Anders, Terzioglu, Mugen, Euro, Liliya, Suomalainen, Anu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754366/
https://ncbi.nlm.nih.gov/pubmed/29302033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01859-9
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