Carregant...

Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA

Autosomal dominant and/or recessive progressive external ophthalmoplegia (ad/arPEO) is associated with mtDNA mutagenesis. It can be caused by mutations in three nuclear genes, encoding the adenine nucleotide translocator 1, the mitochondrial helicase Twinkle or DNA polymerase γ (POLG). How mutations...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Wanrooij, Sjoerd, Luoma, Petri, van Goethem, Gert, van Broeckhoven, Christine, Suomalainen, Anu, Spelbrink, Johannes N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC434440/
https://ncbi.nlm.nih.gov/pubmed/15181170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh634
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!