The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.

Myocardial mitochondrial DNA (mtDNA) copy number decreases in heart failure. In post-myocardial infarction mice, increasing mtDNA copy number by overexpressing mitochondrial transcription factor attenuates mtDNA deficiency and ameliorates pathological remodeling thereby markedly improving survival....

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Autors principals:	Atsushi Tanaka, Tomomi Ide, Takeo Fujino, Ken Onitsuka, Masataka Ikeda, Takako Takehara, Yuko Hata, Emil Ylikallio, Henna Tyynismaa, Anu Suomalainen, Kenji Sunagawa
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2013-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840758/?tool=EBI
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