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Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures
Genome-wide identification of all target proteins of drug candidate compounds is a challenging issue in drug discovery. Moreover, emerging phenotypic effects, including therapeutic and adverse effects, are heavily dependent on the inhibition or activation of target proteins. Here we propose a novel...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760621/ https://ncbi.nlm.nih.gov/pubmed/29317676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18315-9 |
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