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Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures

Genome-wide identification of all target proteins of drug candidate compounds is a challenging issue in drug discovery. Moreover, emerging phenotypic effects, including therapeutic and adverse effects, are heavily dependent on the inhibition or activation of target proteins. Here we propose a novel...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Sawada, Ryusuke, Iwata, Michio, Tabei, Yasuo, Yamato, Haruka, Yamanishi, Yoshihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760621/
https://ncbi.nlm.nih.gov/pubmed/29317676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18315-9
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