β2 adrenergic-neurotrophin feed-forward loop promotes pancreatic cancer

Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines promoted ADRB2 dependent PDAC development, nerve growth factor (NGF) secretion, and pancreatic nerve density. Pancreatic Ngf...

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Publicat a:Cancer Cell
Autors principals: Renz, Bernhard W., Takahashi, Ryota, Tanaka, Takayuki, Macchini, Marina, Hayakawa, Yoku, Dantes, Zahra, Maurer, H. Carlo, Chen, Xiaowei, Jiang, Zhengyu, Westphalen, C. Benedikt, Ilmer, Matthias, Valenti, Giovanni, Mohanta, Sarajo K., Habenicht, Andreas J. R., Middelhoff, Moritz, Chu, Timothy, Nagar, Karan, Tailor, Yagnesh, Casadei, Riccardo, Di Marco, Mariacristina, Kleespies, Axel, Friedman, Richard A., Remotti, Helen, Reichert, Maximilian, Worthley, Daniel L., Neumann, Jens, Werner, Jens, Iuga, Alina C., Olive, Kenneth P., Wang, Timothy C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760435/
https://ncbi.nlm.nih.gov/pubmed/29249692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.007
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