β2 adrenergic-neurotrophin feed-forward loop promotes pancreatic cancer

Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines promoted ADRB2 dependent PDAC development, nerve growth factor (NGF) secretion, and pancreatic nerve density. Pancreatic Ngf...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Renz, Bernhard W., Takahashi, Ryota, Tanaka, Takayuki, Macchini, Marina, Hayakawa, Yoku, Dantes, Zahra, Maurer, H. Carlo, Chen, Xiaowei, Jiang, Zhengyu, Westphalen, C. Benedikt, Ilmer, Matthias, Valenti, Giovanni, Mohanta, Sarajo K., Habenicht, Andreas J. R., Middelhoff, Moritz, Chu, Timothy, Nagar, Karan, Tailor, Yagnesh, Casadei, Riccardo, Di Marco, Mariacristina, Kleespies, Axel, Friedman, Richard A., Remotti, Helen, Reichert, Maximilian, Worthley, Daniel L., Neumann, Jens, Werner, Jens, Iuga, Alina C., Olive, Kenneth P., Wang, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760435/
https://ncbi.nlm.nih.gov/pubmed/29249692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.007
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