Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Fluoropyrimidines (5-fluorouracil, capecitabine) are the mainstay chemotherapeutic agents for the treatment of many types of cancer. Metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD encoded by the DPYD gene) and reduced or absent activity of this enzyme can result in sev...

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Xehetasun bibliografikoak
Argitaratua izan da:Clin Pharmacol Ther
Egile Nagusiak: Amstutz, Ursula, Henricks, Linda M., Offer, Steven M., Barbarino, Julia, Schellens, Jan H.M., Swen, Jesse J., Klein, Teri E., McLeod, Howard L., Caudle, Kelly E., Diasio, Robert B., Schwab, Matthias
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760397/
https://ncbi.nlm.nih.gov/pubmed/29152729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.911
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