Clinical Pharmacogenetics Implementation Consortium (CPIC®) Guideline for CYP2C19 and Voriconazole Therapy

Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 ultrarapid metabolizers have decreased trough voriconazole concentrations, delaying achievement of target blood concentra...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Moriyama, Brad, Owusu Obeng, Aniwaa, Barbarino, Julia, Penzak, Scott R., Henning, Stacey A., Scott, Stuart A., Agúndez, José A. G., Wingard, John R., McLeod, Howard L, Klein, Teri E., Cross, Shane, Caudle, Kelly E., Walsh, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474211/
https://ncbi.nlm.nih.gov/pubmed/27981572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.583
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