Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

Genetic and functional studies underscore the central role of JAK/STAT signaling in myeloproliferative neoplasms (MPN). However, the mechanisms that mediate transformation in MPN are not fully delineated and clinically utilized JAK inhibitors have limited ability to reduce disease burden or reverse...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Kleppe, Maria, Koche, Richard, Zou, Lihua, van Galen, Peter, Hill, Corinne, Dong, Lauren, De Groote, Sofie, Papalexi, Efthymia, Hanasoge Somasundara, Amritha V., Cordner, Keith, Keller, Matthew, Farnoud, Noushin, Medina, Juan, McGovern, Erin, Reyes, Jaime, Roberts, Justin, Witkins, Matthew, Rapaport, Franck, Teruya-Feldstein, Julie, Qi, Jun, Rampal, Raajit, Bernstein, Bradley E., Bradner, James E., Levine, Ross L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760343/
https://ncbi.nlm.nih.gov/pubmed/29249691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.009
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