The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ

Replicative DNA polymerases cannot insert efficiently nucleotides at sites of base lesions. This function is taken over by specialized translesion DNA synthesis (TLS) polymerases to allow DNA replication completion in the presence of DNA damage. In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitin...

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Bibliografische gegevens
Gepubliceerd in:PLoS Genet
Hoofdauteurs: Tellier-Lebegue, Carine, Dizet, Eléa, Ma, Emilie, Veaute, Xavier, Coïc, Eric, Charbonnier, Jean-Baptiste, Maloisel, Laurent
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760103/
https://ncbi.nlm.nih.gov/pubmed/29281621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007119
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